M. Born et al., Plant 2000 - An exercise in the benchmarking of multipurpose chemical manufacturing plants in the pharmaceutical sector, CHIMIA, 54(12), 2000, pp. 724-730
A study was performed to compare the investment costs and functionality of
a number of different multipurpose chemical manufacturing plants, all used
for the manufacture of active pharmaceutical ingredients and their intermed
iates. In parallel the functionality required to process a large number of
steps was assessed and the results of the two studies were combined. A desc
ription of the methodology and of the key findings is given.