Silent ischemic interval on exercise test is a predictor of response to drug therapy: A randomized crossover trial of metoprolol versus diltiazem in stable angina
Sk. Dwivedi et al., Silent ischemic interval on exercise test is a predictor of response to drug therapy: A randomized crossover trial of metoprolol versus diltiazem in stable angina, CLIN CARD, 24(1), 2001, pp. 45-49
Background and hypothesis: There is no method available to predict the rela
tive antianginal efficacy of beta blockers and calcium-channel antagonists.
The present study was undertaken to assess the role of silent ischemic int
erval (SII) on exercise treadmill test (ETT) as a predictor of response to
therapy with metoplolol and diltiazem in patients with stable angina.
Methods: Thirty-four patients with stable angina were divided into two grou
ps depending upon the presence or absence of an SII gap of at least 1 min b
etween onset of ST depression and appearance of angina on ETT. Metoprolol (
50-100 mg twice daily) and diltiazem (60-120 mg three times daily) were ran
domly assigned for 6 weeks to patients in each group, and then patients wer
e crossed over for further 6 weeks after a washout period of weeks. Antiang
inal efficacy was assessed by clinical and exercise parameters.
Results: In patients with SII, the clinical responder rate was better with
metoprolol than with diltiazem (90 vs. 60%, respectively), and on ETT, meto
prolol produced significant improvement in the total exercise lime (p < 0.0
1), time to 1 min ST depression (p < 0.01), time to angina (p < 0.01), and
a significant decrease in peak rate-pressure product (p < 0.001), whereas d
iltiazem had no significant effect on exercise parameters. However, in pati
ents without SII, metoprolol and diltiazem had a similar clinical responder
rate (57%), and both produced a significant increase in total exercise tim
e (p < 0.01), time to 1 mm ST depression (p < 0.01), and time to angina (p
< 0.01). In addition, metoprolol had a significant effect on peal; rate-pre
ssure product (p < 0.001).
Conclusion: Silent ischemic interval on ETT can be a predictor of response
to antianginal therapy in stable angina, as patients with SII respond bette
r to metoprolol and those without SII respond equally to both metoprolol an
d diltiazem.