Nodular fasciitis is a benign, reactive fibroblastic soft tissue tumor. Inv
olvement of the hand is exceedingly rare. A case of nodular fasciitis invol
ving the dominant hand of a 38-year-old woman is reviewed, and its clinicop
athologic features are presented. Because of its rapid growth and aggressiv
e histologic appearance, nodular fasciitis can be mistaken for a soft tissu
e sarcoma, despite its benign clinical behavior. For this reason, aggressiv
e surgical resection should be avoided.