Chronic myelogenous leukemia

Chronic myelogenous leukemia (CML) is a clonal hematopoietic stem cell diso rder characterized by the (9:22) translocation and resultant production of the constitutively activated bcr-abl tyrosine kinase. Characterized clinica lly by marked myeloid proliferation, it invariably terminates in an acute l eukemia. Interferon-based regimens and stem cell transplantations are the s tandard therapeutic options, with stem cell transplantation being the only curative therapy. As therapy for CML improves, molecular methods of monitor ing response will become integrated in patient treatment. Through rational drug development, ST1571, a bcr-abl tyrosine kinase inhibitor, has emerged as targeted therapy that offers new hope for expanded treatment options for patients with CML. Curr Opin Oncol 2001, 13:3-7 (C) 2001 Lippincott Willia ms & Wilkins, inc.