We study the impact of a high-speed connection between two regional economi
es on the location of production activities, using the simple plant-locatio
n problem and toy networks. As expected, the relative value of fixed produc
tion costs to transportation costs is crucial in the determination of facil
ity locations. Less expected is the fairly strong instability observed in t
he structure of the locational pattern of facilities when the relative valu
e of the fixed costs changes. The construction of a piece of infrastructure
has an impact on the regional structure of production provided that it all
ows for a substantial reduction in transport spending. When scale economies
in production are large, one regional center swallows up the other and may
eventually become the only production center within the integrated economy
.