The relationship of placental bed biopsy findings and fibronectin levels with the clinical severity of preeclampsia syndrome

The aim of the study was to evaluate the relation between placental bed bio psy findings and fibronectin levels with the clinical severity of preeclamp sia syndrome. Thirty-five women with preeclampsia/eclampsia were compared w ith 25 healthy women with uncomplicated pregnancies. Serum levels of fibron ectin were measured by radial immundiffusion technic, Twenty-one placental bed biopsies from preeclamptic pregnancies were compared with 17 from norma l pregnancies. Placental bed biopsies were taken at caesarean section. In p reeclampsia/eclampsia, fibronectin levels were higher than in normal pregna ncy. Normotensive women all had normal placental bed biopsy findings and th e incidence of pathological bed biopsy findings increased with the severity of the preeclampsia. The plasma levels of fibronectin were significantly i ncreased with the increments in diastolic blood pressure (r=0.49, p<0.001). As a conclusion, the present study confirms a relation between the patholo gical events in the placental bed and endothelial damage in preeclampsia.