H. Watanabe et al., Frequency-dependent electrophysiological effects of flecainide, nifekalantand d,l-sotalol on the human atrium, JPN CIRC J, 65(1), 2001, pp. 1-6
Citations number
29
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
To compare the effects of class Ic and III antiarrhythmic agents on the ter
mination and prevention of atrial fibrillation, the present study investiga
ted the use-dependent electrophysiological effects of flecainide, nifekalan
t and d,l-sotalol on the human atrium. Flecainide significantly prolonged e
ffective refractory period (ERP), intra-atrial conduction time (IACT) and m
onophasic action potential duration (MAPD), and its effects on ERP and IACT
were use-dependent. Nifekalalant significantly prolonged ERP and MAPD, and
these effects were reverse use-dependent; however, there was no significan
t change in IACT. ci,l-Sotalol significantly prolonged MAPD and the effect
was reverse use-dependent. It significantly prolonged ERP, but the effect w
as not reverse use-dependent. d,l-Sotalol increased IACT in a use-dependent
manner. Thus, for atrial fibrillation, class Ic antiarrhythmic agents migh
t be more effective in termination and class III antiarrhythmic agents migh
t be more effective in prevention.