Mitochondrial lipid peroxides and antioxidant enzymes in colorectal adenocarcinoma tissues

Lipid peroxide levels and superoxide dismutase (SOD), glutathione peroxidas e (GSH-Px), and glutathione transferase (GST) activities were investigated in mitochondrial fractions obtained from tumorous and nontumorous colorecta l tissues of fourteen patients with colon and rectum cancer. Histopathologi cal evaluations, including type, stage, necrosis and lymphocyte infiltratio n were also performed for each patient. The activities of SOD, GSH-Px and G ST were increased significantly, but lipid peroxide levels remained unchang ed in mitochondria obtained from tumors compared to adjacent normal tissues of subjects with colorectal cancer. When the patients mere grouped accordi ng to their histopathological evaluation, such as type, stage, necrosis and lymphocyte infiltration, no relationship was observed between the histopat hological results and the mitochondrial lipid peroxidation or antioxidant e nzyme activities.