Synthesis of N-4909 analogs part I. A stimulant of apolipoprotein E secretion in human hepatoma G2 cells

Authors
Yanai, M Suzuki, M Kawamura, K Oshida, N Hiramoto, S Yasuda, O Shingai, A Suguro, T
Citation
M. Yanai et al., Synthesis of N-4909 analogs part I. A stimulant of apolipoprotein E secretion in human hepatoma G2 cells, J ANTIBIOT, 53(12), 2000, pp. 1385-1396
Citations number
6
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF ANTIBIOTICS
ISSN journal
00218820 → ACNP
Volume
53
Issue
12
Year of publication
2000
Pages
1385 - 1396
Database
ISI
SICI code
0021-8820(200012)53:12<1385:SONAPI>2.0.ZU;2-F
Abstract
Analogs of N-4909 (1), which had a stimulating activity for apolipoprotein E (apo E) secretion in Human hepatoma Hep G2 cells, were prepared and their activities examined. Cyclic analogs which had different kinds of amino aci ds or different number of amino acids from N-4909 (1) showed less effect on apo E secretion from Hep G2 cells. The length of acyl chain was found to b e an important factor for the activity. Shorter chain reduced the activity. Linear analogs were also prepared. One of their analogs, N-5849 (17), whic h had six amino acids was found to have strong activity.