ANTIBIOTIC-THERAPY IN MEN WITH LEUKOCYTOSPERMIA

Objective-In this prospective study, we aimed to determine the efficac y of doxycycline and doxycycline plus ceftriaxone for the treatment of asymptomatic men with leukocytospermia. Method-Seventy men were inclu ded in this randomized and placebo-controlled study. White blood cell (WBC) concentrations were determined by peroxidase assay during the ro utine semen analysis. Twenty-four of 70 men with leukocytospermia were randomized as control group and administered placebo (group I), 25 re ceived doxycycline alone (group II), and 21, doxycycline plus ceftriax one (group III). Doxycycline, 100 mg, was given twice a day for ten da ys and ceftriaxone, 1 g, in two doses for only one day. After the trea tment, semen analyses were repeated. Results-After the treatment there was a significant decrease in WBC counts in groups II and II when com pared with group I (P < .05). Both antibiotic regimens were found to b e equally effective. However, the time needed for resolution of leukoc ytospermia (similar to 4 weeks) was similar between the control and tr eatment groups. Conclusion-Although both antibiotic regimens significa ntly, and equally improved the white blood cell counts in men with leu kocytospermia, they failed to treat the leukocytospermia, i.e., to bri ng the count below the limit of one million WBC/mL. Therefore, it is d oubtful that antibiotic therapy should be recommended for asymptomatic men with leukocytospermia.