Biomesogenic matrix systems

The bifunctionally reactive nucleoside and distant nucleoside analogs adeno sine (Ado), S-[(adenine-9-yl)methoxyethyl]-L-cysteine (Na-salt) (cysA) and 9-vinyladenine (vA) in aqueous solutions assemble on complementary polyurid ylic acid templates to form complex lyomesophases. The systems are investig ated by polarizing microscopy, differential scanning calorimetry (DSC) and H-1- and P-31-nmr spectroscopies, assisted by molecular modeling studies. T he results indicate the importance of biomesogenic (pre)ordering in nucleic acid native and artificial matrix reactions.