Combined treatment with haloperidol and trazodone in patients with tic disorders

The combination of haloperidol and trazodone was evaluated in an open-label trial in 10 patients with chronic tic and Tourette's syndrome. We found a mean reduction of symptoms of 58.9% on the Yale Global Tic severity Scale, with a statistically significant difference (p < 0.001) between the baselin e and endpoint treatment conditions. This approach significantly reduces cl inical symptoms, with the advantage of a lower dose of haloperidol than usu al, with no side effects reported by the patients.