Mhk. Leidenius et al., COLORECTAL DYSPLASIA AND CARCINOMA IN PATIENTS WITH ULCERATIVE-COLITIS AND PRIMARY SCLEROSING CHOLANGITIS, Scandinavian journal of gastroenterology, 32(7), 1997, pp. 706-711
Background: The aim of this study was to evaluate the role of primary
sclerosing cholangitis (PSC) as a cofactor in the dysplasia-carcinoma
sequence in ulcerative colitis (UC). Methods: Forty-five patients with
UC and concomitant PSC and 45 pair-matched control patients with UC o
nly were examined for colorectal dysplasia and carcinoma. Results: The
median duration of UC was 11 years in the group with UC and PSC and l
j years in the control group. Thirteen of the 45 patients (29%) with U
C and PSC had colorectal neoplasia: 4, carcinoma; 2, high-grade dyspla
sia; and 7, low-grade dysplasia. Four of the 45 control patients (9%)
had neoplastic findings: 1, carcinoma; 1, high-grade dysplasia, and 2,
low-grade dysplasia (P < 0.05). Conclusion: The results suggest that
the risk of colorectal dysplasia and carcinoma in patients with UC is
increased by concomitant PSC.