HPLC analysis of tiaprofenic acid in the samples of whole blood using L-L and S-L extractions

Authors
Sochor, J Klimes, J Sedlacek, J Somolikova, B Slovencik, D
Citation
J. Sochor et al., HPLC analysis of tiaprofenic acid in the samples of whole blood using L-L and S-L extractions, J LIQ CHR R, 23(20), 2000, pp. 3191-3201
Citations number
16
Categorie Soggetti
Chemistry & Analysis","Spectroscopy /Instrumentation/Analytical Sciences
Journal title
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
ISSN journal
10826076 → ACNP
Volume
23
Issue
20
Year of publication
2000
Pages
3191 - 3201
Database
ISI
SICI code
1082-6076(2000)23:20<3191:HAOTAI>2.0.ZU;2-Q
Abstract
In order to evaluate tiaprofenic acid in the samples of whole blood, method s of extraction on solid phases (SLE) and those of extraction into an organ ic solvent (LLE) were worked out and the suitability of its use for HPLC an alysis of tiaprofenic acid was compared. SLE was carried out on the solid p hases C-18 and LLE into dichloromethane. Prior to the commencement of extractions, stability of tiaprofenic acid was examined. After the adjustment of the sample by a selected method of extra ction (SLE), tiaprofenic acid was evaluated in blood in a two-how pharmacok inetic study.