New malyngamides from the Hawaiian cyanobacterium Lyngbya majuscula

Citation
Y. Kan et al., New malyngamides from the Hawaiian cyanobacterium Lyngbya majuscula, J NAT PROD, 63(12), 2000, pp. 1599-1602
Citations number
32
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
63
Issue
12
Year of publication
2000
Pages
1599 - 1602
Database
ISI
SICI code
0163-3864(200012)63:12<1599:NMFTHC>2.0.ZU;2-E
Abstract
Isomalyngamides A and B (1, 2) were isolated and characterized from a colle ction of the cyanobacterium Lyngbya majuscula from Hawaiian waters. These c ompounds represent a new type of malyngamide, similar to malyngamides Q and R, in which the conformation of the chloromethylene group is opposite from the majority of previously reported malyngamides. The geometry of the chlo romethylene moiety was elucidated from the long-range coupling constants (( 3)J(C-H)) Obtained from editing-HETLOC and phase-sensitive HMBC experiments . Isomalyngamides A and B (1, 2) showed lethal toxicity to crayfish.