New cytotoxic sesquiterpenes from the gorgonian Isis hippuris

Five new suberosane sesquiterpenes, suberosenol A (1), suberosenol B (2), s uberosanone (3), suberosenol A acetate (4), and suberosenol B acetate (5), along with the known sesquiterpene subergorgic acid (6), have been isolated from the gorgonian Isis hippuris. The structures of these metabolites were established by spectroscopic and chemical methods. Metabolites 1 and 3-5 w ere found to exhibit potent cytotoxicity toward P-388, A549, and HT-29 canc er cell lines.