Ycq. Zang et al., Regulation of chemokine receptor CCR5 and production of RANTES and MIP-1a by interferon-beta, J NEUROIMM, 112(1-2), 2001, pp. 174-180
Trafficking of inflammatory T cells into the brain is associated with inter
actions of certain chemokines with their receptors, which plays an importan
t role in the pathogenesis of multiple sclerosis (MS). We examined whether
interferon-beta (IFN-beta) had the ability to regulate the production of ch
emokines and the expression of their receptors in T cells derived from pati
ents with MS. It was demonstrated for the first time that in vitro exposure
of T cells to IFN-beta -1a selectively inhibited mRNA expression for RANTE
S and MIP-1 alpha and their receptor CCR5. T cell surface expression of CCR
5 was significantly reduced in MS patients treated with IFN-beta, correlati
ng with decreased T cell transmigration toward RANTES and MIP-1 alpha. The
study provides new evidence suggesting that IFN-beta treatment impairs chem
okine-induced T cell trafficking by reducing the production of RANTES and M
IP-1 alpha and the expression of their receptors CCR5. (C) 2001 Elsevier Sc
ience B.V. All rights reserved.