Adaptation of the exocrine pancreas to dietary fats

This article reviews studies on the adaptation of the exocrine pancreas to dietary fat. We include all the latest information about the mechanisms tha t underlie the adaptation of the secretory mechanism of the exocrine pancre as to the amount and the type of dietary fat. We review the kinetics of pan creatic adaptation and the mediators of the adaptive response of the pancre as including cellular and molecular mechanisms (modulation of intracellular messengers and gene expression of the different enzymes and secretagogues involved in the adaptation process). At: the same time we include our resul ts in this field in dogs and humans.