Weighting function used for adjustment of multiple-bolus drug dosing

This paper-presents a new: method for the adjustment of the multiple-bolus dosing of a drug. The method is based on the weighting function of the syst em describing the behavior (absorption) distribution and elimination of the drug in the patient. identified employing a test dose administration of th e drug to a patient. This method can br employed for the adjustment of the multiple-bolus dosing of the drugs whose behavior in the patient can be suf ficiently described by linear time invariant models. The method allows to e stimate loading and maintenance bolus doses of the drug, necessary to reach and maintain prescribed trough levels of the drug ill a patient at desired time-points, both (the levels and time-points) specified by treatment requ irements. The method is particularly suitable for lire adjustment of multip le-bolus dosing of drugs with narrow therapeutical windows of of very expen sive products such trs the cloning factors. The methods is exemplifies by t he adjustment of the multiple-bolus dosing of factor VIII in postoperative treatment of hemophilia A. (C) 2000 Prous Science. All rights reserved.