Structure and function of tmRNA (10Sa RNA)

Authors
Zvereva, ME Shpanchenko, OV Dontsova, OA Bogdanov, AA
Citation
Me. Zvereva et al., Structure and function of tmRNA (10Sa RNA), MOL BIOL, 34(6), 2000, pp. 927-933
Citations number
49
Categorie Soggetti
Molecular Biology & Genetics
Journal title
MOLECULAR BIOLOGY
ISSN journal
00268933 → ACNP
Volume
34
Issue
6
Year of publication
2000
Pages
927 - 933
Database
ISI
SICI code
0026-8933(200011/12)34:6<927:SAFOT(>2.0.ZU;2-2
Abstract
Modern data on the structure and function of transport/messenger (tm) RNA a re reviewed. This stable RNA is involved in releasing ribosomes that are un able to complete protein synthesis on mRNA lacking the stop codon. The resu lting abnormal proteins are rapidly degraded by specific proteases, which r ecognize a signal peptide encoded by the template region of tmRNA. The disc overy of trans-translation has caused a particular interest in structural a nd functional studies of tmRNA.