KETOPROFEN SODIUM - PREPARATION AND ITS FORMATION OF MIXED-CRYSTALS WITH KETOPROFEN

A simple two-step process for the preparation of ketoprofen sodium was developed. The procedure involved dissolution of ketoprofen in ethano lic NaOH followed by evaporation of the solvent. The resulting amorpho us solid was crystallized by controlled precipitation from 96% ethanol . The sodium salt proved to be stable for 4 years and its aqueous solu tions for at least 1 year (investigated period). Ketoprofen sodium app ears to be an alternative bulk form to ketoprofen acid for production of formulations after further characterization of the compound.