Susceptibility to oxidation of plasma low-density lipoprotein in X-linked adrenoleukodystrophy: Effects of simvastatin treatment

Authors
Di Biase, A Salvati, S Vari, R Avellino, C Sforza, F Cappa, M Masella, R
Citation
A. Di Biase et al., Susceptibility to oxidation of plasma low-density lipoprotein in X-linked adrenoleukodystrophy: Effects of simvastatin treatment, MOL GEN MET, 71(4), 2000, pp. 651-655
Citations number
27
Categorie Soggetti
Molecular Biology & Genetics
Journal title
MOLECULAR GENETICS AND METABOLISM
ISSN journal
10967192 → ACNP
Volume
71
Issue
4
Year of publication
2000
Pages
651 - 655
Database
ISI
SICI code
1096-7192(200012)71:4<651:STOOPL>2.0.ZU;2-0
Abstract
This paper shows for the first time the higher oxidizability of low-density lipoprotein (LDL) in plasma from adrenoleukodystrophy (ALD) patients compa red to that of control subjects. LDL oxidation susceptibility was assessed by conjugate diene formation, hydroperoxide and lipoperoxide formation, and electrophoretic mobility. Simvastatin therapy, an HMG-CoA reductase inhibi tor, seems to be a protective pharmacological agent against the higher oxid izability of LDL in plasma from ALD patients. (C) 2000 Academic Press.