Protein interaction maps for model organisms

Citation
Ajm. Walhout et M. Vidal, Protein interaction maps for model organisms, NAT REV MOL, 2(1), 2001, pp. 55-62
Citations number
77
Categorie Soggetti
Cell & Developmental Biology
Journal title
NATURE REVIEWS MOLECULAR CELL BIOLOGY
ISSN journal
14710072 → ACNP
Volume
2
Issue
1
Year of publication
2001
Pages
55 - 62
Database
ISI
SICI code
1471-0072(200101)2:1<55:PIMFMO>2.0.ZU;2-Y
Abstract
Until recently. classical genetics and biochemistry were the main technique s used to investigate how organisms develop, reproduce, behave and age. But with the availability of complete genome sequences new approaches are emer ging. Complete sets of proteins 'proteomes' - can be predicted from genome sequences and used to characterize protein functions globally. For example. through the large-scale identification of physical protein-protein interac tions, comprehensive protein interaction maps are being generated. And thes e maps might help us to understand the processes that control the biology o f living organisms.