The splice of life: Alternative splicing and neurological disease

Citation
Bk. Dredge et al., The splice of life: Alternative splicing and neurological disease, NAT REV NEU, 2(1), 2001, pp. 43-50
Citations number
96
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NATURE REVIEWS NEUROSCIENCE
ISSN journal
14710048 → ACNP
Volume
2
Issue
1
Year of publication
2001
Pages
43 - 50
Database
ISI
SICI code
1471-0048(200101)2:1<43:TSOLAS>2.0.ZU;2-P
Abstract
Splicing of pre-messenger RNA is regulated differently in the brain compare d with other tissues. Recognition of aberrations in splicing events that ar e associated with neurological disease has contributed to our understanding of disease pathogenesis in some cases. Neuron-specific proteins involved i n RNA splicing and metabolism are also affected in several neurological dis orders. These findings have begun to bridge what we know about the mechanis ms regulating neuron-specific splicing and our understanding of neural func tion and disease.