Primus inter pares (First among equals)

Authors
Keck, JL Berger, JM
Citation
Jl. Keck et Jm. Berger, Primus inter pares (First among equals), NAT ST BIOL, 8(1), 2001, pp. 2-4
Citations number
29
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NATURE STRUCTURAL BIOLOGY
ISSN journal
10728368 → ACNP
Volume
8
Issue
1
Year of publication
2001
Pages
2 - 4
Database
ISI
SICI code
1072-8368(200101)8:1<2:PIP(AE>2.0.ZU;2-7
Abstract
Priming of DNA replication in eukaryotes is carried out by a heterotetramer ic complex known as pol alpha -primase. The structure of the Pyrococcus fur iosus RNA polymerase subunit of this complex shows that priming is carried out by unrelated proteins in archaea/eukarya and eubacteria, provides insig hts into the mechanism of action of a novel RNA polymerase, and raises new questions regarding the ancestry of priming and replication in the three do mains of life.