Basal expression of bradykinin B-1 receptor in peripheral sensory ganglia in the rat

The bradykinin B-1 receptor is thought to be induced by tissue injury and i nflammation. In the present study, we have investigated whether there is a basal expression of B-1 receptor in dorsal root ganglion (DRG) and trigemin al ganglion neurons in rats. A substantial number of neurons in both DRGs a nd trigeminal ganglia were found to be B-1-immunoreactive in rats. Both sma ll and medium-sized DRG neurons were Bi-immunoreactive, suggesting that the y are likely to be A delta- or C-fibre neurons which are involved in nocice ptive transmission. These results support a possible role for B-1 receptors in the modulation of nociceptive sensory transmission. NeuroReport 11:4003 -4005 (C) 2000 Lippincott Williams & Wilkins.