Recent investigations have demonstrated that temporal patterns of sensory n
eural activity detected by magnetoencephalography (MEG) reflect features of
the stimulus. In this study, neuromagnetic activity was investigated using
an event detection algorithm based on the correlation coefficient. The res
ults of the technique are compared with widely used methods of analysis in
two experimental conditions and are shown to identify features in the singl
e-trial MEG response that are not apparent in the response obtained by aver
aging across repeated trials. As an example of the technique, the physiolog
ic jitter in latency associated with the M100 of auditory evoked fields was
reproducibly measured. Specifically, higher intensity sounds were associat
ed with an increased reliability. The technique was also applied to the noi
se-enhanced evoked auditory response, producing an objective demonstration
of a cortical manifestation of the phenomenon of stochastic resonance-the p
aradoxical enhancement in the measurement of the signal-to-noise ratio (SNR
) induced by optimal addition of noise to system input. NeuroReport 11:4081
-4085 (C) 2000 Lippincott Williams & Wilkins.