Topical 0.1% indomethacin solution versus topical 0.1% dexamethasone solution in the prevention of inflammation after cataract surgery

Purpose: To compare the efficacy and safety of topical 0.1% indomethacin wi th 0.1% dexamethasone after cataract surgery. Methods: 145 patients (indo = 71, dexa = 74) were enrolled in a randomised, double-masked study and rece ived one drop 4 times a day of indomethacin or dexamethasone for 1 month. R esults: Proteinic flare and cellular Tyndall decreased with time in both gr oups, with a difference in favour of indomethacin for cellular Tyndall on d ay 30 (p = 0,046). Conjunctival hyperaemia was less pronounced in the dexam ethasone group on day 30 (p = 0,03), Tolerance of both drugs was good. Conc lusion: 0.1% Indomethacin solution appears to be as safe and efficient as 0 .1% dexamethasone eyedrops in the management of post-operative inflammation and could be a good alternative to the use of steroids. Copyright (C) 2001 S. Karger AG, Basel.