Enantioselective addition of 2-methyl-3-butyn-2-ol to aldehydes: Preparation of 3-hydroxy-1-butynes

Authors
Boyall, D Lopez, F Sasaki, H Frantz, D Carreira, EM
Citation
D. Boyall et al., Enantioselective addition of 2-methyl-3-butyn-2-ol to aldehydes: Preparation of 3-hydroxy-1-butynes, ORG LETT, 2(26), 2000, pp. 4233-4236
Citations number
17
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
2
Issue
26
Year of publication
2000
Pages
4233 - 4236
Database
ISI
SICI code
1523-7060(200012)2:26<4233:EAO2TA>2.0.ZU;2-S
Abstract
[GRAPHICS] We report the first example of enantioselective aldehyde additions of 2-met hyl-3-butyn-2-ol, a commodity bulk chemical that is readily available. Foll owing a facile fragmentation reaction, the addition reactions provide acces s to optically active terminal acetylenes as useful building blocks for asy mmetric synthesis.