Anti-hepatitis B virus effects of wogonin isolated from Scutellaria baicalensis

Authors
Huang, RL Chen, CC Huang, HL Chang, CG Chen, CF Chang, CM Hsieh, MT
Citation
Rl. Huang et al., Anti-hepatitis B virus effects of wogonin isolated from Scutellaria baicalensis, PLANTA MED, 66(8), 2000, pp. 694-698
Citations number
14
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PLANTA MEDICA
ISSN journal
00320943 → ACNP
Volume
66
Issue
8
Year of publication
2000
Pages
694 - 698
Database
ISI
SICI code
0032-0943(200012)66:8<694:ABVEOW>2.0.ZU;2-E
Abstract
By using an HBV-producing cell line (MS-G2) in vitro culture system, we fou nd that wogonin isolated from Scutellaria baicalensis can suppress HBV surf ace antigen production (P < 0.001) without evidence of cytotoxicity. By ass aying the endogenous HBV DNA polymerase activity, we found that both the re laxed circular and the linear forms of HBV DNA are significantly reduced in the wogonin-treated group. Wogonin deserves to be further evaluated for th e treatment of human HBV infection.