Inhibition of neutrophil elastase activity by cinnamic acid derivatives from Cimicifuga racemosa

Authors
Loser, B Kruse, SO Melzig, MF Nahrstedt, A
Citation
B. Loser et al., Inhibition of neutrophil elastase activity by cinnamic acid derivatives from Cimicifuga racemosa, PLANTA MED, 66(8), 2000, pp. 751-753
Citations number
13
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PLANTA MEDICA
ISSN journal
00320943 → ACNP
Volume
66
Issue
8
Year of publication
2000
Pages
751 - 753
Database
ISI
SICI code
0032-0943(200012)66:8<751:IONEAB>2.0.ZU;2-T
Abstract
Caffeic acid, fukinolic acid as well as cimicifugic acids A, B, E and F iso lated from the rhizomes of Cimicifuga racemosa (Ranunculaceae) inhibited th e activity of neutrophil elastase (EC 3.4.21.37) in a dose-dependent manner . An IC50 of 93 mu mol/ L was determined for caffeic acid and 0.23 mu mol/L for fukinolic acid. Cimicifugic acid A inhibited the enzyme with an IC50 o f 2.2 mu mol/L, cimicifugic acid B with 11.4 mu mol/L, and cimicifugic acid F with 18 mu mol/L. Cimicifugic acid E was only a very weak inhibitor.