From the leaves of Ligularia fischeri var. spiciformis, a new eremophilanol
ide, 8 alpha -methoxy-6-oxoeremophil-7(11)-en-12,8-olide (6-oxoeremophileno
lide) and a eudesmane-type sesquiterpene, (+)-intermedeol were isolated. Th
e structures were determined on the basis of 2D-NMR spectral data. Data on
cytotoxicity showed that the latter was clearly more potent than the former
compound.