Twisting and stretching single DNA molecules

Authors
Strick, T Allemand, JF Croquette, V Bensimon, D
Citation
T. Strick et al., Twisting and stretching single DNA molecules, PROG BIOPHY, 74(1-2), 2000, pp. 115-140
Citations number
107
Categorie Soggetti
Molecular Biology & Genetics
Journal title
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
ISSN journal
00796107 → ACNP
Volume
74
Issue
1-2
Year of publication
2000
Pages
115 - 140
Database
ISI
SICI code
0079-6107(2000)74:1-2<115:TASSDM>2.0.ZU;2-F
Abstract
The elastic properties of DNA are essential for its biological function. Th ey control its bending and twisting as well as the induction of structural modifications in the molecule. These call affect its interaction with the c ell machinery. The response of a single DNA molecule to a mechanical stress can be precisely determined in single-molecule experiments which give acce ss to an accurate measurement of the elastic parameters of DNA. (C) 2000 Pu blished by Elsevier Science Ltd. All rights reserved.