This study sought to experimentally validate 2 self-reported trigger f
actors of headaches, namely negative affect (anxiety, depression, and
anger) and hunger, and to investigate whether these triggers activated
the same or different physiological mechanisms. Students (38 women an
d 18 men) who had suffered from frequent headaches (migraine or tensio
n type) for 6 months or more were randomly assigned to 4 conditions, w
hich involved manipulating hunger by means of 19 hr of food deprivatio
n and negative affect by means of a stressor (difficult to solve anagr
ams). The findings were consistent with self-reports that hunger and n
egative affect can precipitate headaches in individuals who suffer fro
m both migraine and tension-type headaches. The physiological response
s to the experimental conditions differed, but the findings were not c
onclusive with respect to whether the trigger factors operated by mean
s of a common biological pathway.