Synthesis of aminomethyl derivatives of 3-methyl-4,7-dihydro-3H-imidazo[4,5-d][1,2,3]triazin-4-one

Authors
Rusinov, GL Ishmetova, RI Selezneva, IS Kalugina, TA
Citation
Gl. Rusinov et al., Synthesis of aminomethyl derivatives of 3-methyl-4,7-dihydro-3H-imidazo[4,5-d][1,2,3]triazin-4-one, RUSS J ORG, 36(6), 2000, pp. 873-876
Citations number
8
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY
ISSN journal
10704280 → ACNP
Volume
36
Issue
6
Year of publication
2000
Pages
873 - 876
Database
ISI
SICI code
1070-4280(200006)36:6<873:SOADO3>2.0.ZU;2-N
Abstract
New aminomethyl derivatives of 3-methyl-4,7-dihydro-3H-imidazo[4,5-d][1,2,3 ]triazin-4-one were synthesized by Mannich reaction. These Mannich bases is also possible to prepare by reaction of 7(5)-hydroxymethyl-3-methyl-4,7(5) dihydro-3H-imidazo[4,5-d][1,2,3]triazin-4-one with amines. The compounds ob tained exist in solutions as mixtures of N-5 and N-7 isomers, and the fract ion of the latter grows with the polarity of the solvent.