The use of betamethasone and hyaluronidase injections in the treatment of Peyronie's disease

Citation
A. Lamprakopoulos et al., The use of betamethasone and hyaluronidase injections in the treatment of Peyronie's disease, SC J UROL N, 34(6), 2000, pp. 355-360
Citations number
15
Categorie Soggetti
Urology & Nephrology
Journal title
SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY
ISSN journal
00365599 → ACNP
Volume
34
Issue
6
Year of publication
2000
Pages
355 - 360
Database
ISI
SICI code
0036-5599(200012)34:6<355:TUOBAH>2.0.ZU;2-X
Abstract
Objective: The aim of this study was to assess the effect of local injectio ns of betamethasone, hyaluronidase and lidocaine in patients with Peyronie' s disease. Material and methods: A total of 112 men who had a palpable plaq ue at the penis and suffered from painful erection and bending of penis was treated with a total of 12 injections containing betamethasone, hyaluronid ase and lidocaine. Patients were classified into groups according to the du ration of the disease (<6 months, 6-12 months or >12 months) as well as the size of the plaque (<10 mm, 10-20 mm or >20 mm). Pretreatment evaluation o f patients and assessment of outcome were based on subjective criteria as w ell as measurement of the size of the plaque by means of ultrasound. Result s were correlated to patients' characteristics. Results: The overall respon se rate was 86%. Cure or improvement was noticed in 31% and 55% of patients respectively. Most of the patients (83%) had a duration of disease less th an 12 months. Painful erection, bending of penis and plaque were absent in 97%, 32% and 31% of patients, respectively, after treatment. No severe comp lications were observed. The effect of treatment was strongly related to th e duration of disease and the size of the plaque. Conclusions: The method i s safe, well tolerated by patients and characterized by a high response rat e in patients with a history of less than 12 months and a plaque not exceed ing 20 mm.