Obscure gastrointestinal (GI) bleeding is relatively common but difficult t
o manage. By definition, diagnosis of a specific etiology is particularly c
hallenging. We report the diagnostic use of provocative angiography in a pa
tient with recurrent obscure GI bleeding. Although provocative angiography
led to localization of bleeding and allowed specific treatment (placement o
f a 2-mm long, 0.010-inch diameter platinum coil, resulting in cessation of
bleeding for 2 months), ultimately, the use of provocative angiography del
ayed specific diagnosis in our patient. We conclude that provocative angiog
raphy is a potentially powerful adjunct in the management of obscure GI ble
eding, but that caution is required when using it. Provocative angiography
should be reserved for patients who have had adequate imaging studies with
negative results.