We present possibly the first reported case of prosthetic joint infection d
ue to group C Streptococcus in a 53-year-old man. The patient was heated wi
th surgical debridement along with extended intravenous antibiotics and lon
g-term oral penicillin therapy. He was able to retain the prosthesis and at
4-year follow-up had no symptoms or evidence of recurrent clinical infecti
on.