CAL-B catalyzed enantioselective synthesis of cyanohydrins - A facile route to versatile building blocks

Authors
Hanefeld, U Li, YX Sheldon, RA Maschmeyer, T
Citation
U. Hanefeld et al., CAL-B catalyzed enantioselective synthesis of cyanohydrins - A facile route to versatile building blocks, SYNLETT, (12), 2000, pp. 1775-1776
Citations number
20
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNLETT
ISSN journal
09365214 → ACNP
Issue
12
Year of publication
2000
Pages
1775 - 1776
Database
ISI
SICI code
0936-5214(200012):12<1775:CCESOC>2.0.ZU;2-T
Abstract
A straightforward process for the preparation of optically active cyanohydr ins, important building blocks for the synthesis of drugs and agrochemicals , has been established. Lipase B from Candida antarctica (CAL-B)catalyzes t he kinetic resolution of racemic cyanohydrin acetates under mild conditions : optimization of the process led to a user-friendly synthesis of (S)- and (R)-cyanohydrins.