Supported reagents: Opportunities and limitations

The irt vitro testing of collections of compounds has reached a stage where more compounds can be tested than can be synthesised. To keep up with this demand chemists have turned towards investigating parallel synthesis metho ds, which reduce the time spent in the work-up of a reaction. The vast lite rature regarding solution-phase chemistry and simple reaction monitoring ha s encouraged chemists to consider synthesis in solution-phase with the aid of supported reagents. Although the first developments were published over three decades ago, only recently has their appeal reached a wider audience. 1 Introduction 2 Oxidations using supported reagents 3 Reductions using supported reagents 4 Supported triphenylphosphine 5 Supported nucleophiles 6 Supported bases 7 Supported coupling reagents 8 Supported catalysts 9 Multi-step synthesis using supported reagents 10 Conclusions and outlook.