Etiology and pathophysiology of chronic transplant dysfunction

Citation
Ea. Kouwenhoven et al., Etiology and pathophysiology of chronic transplant dysfunction, TRANSPLAN I, 13(6), 2000, pp. 385-401
Citations number
236
Categorie Soggetti
Surgery
Journal title
TRANSPLANT INTERNATIONAL
ISSN journal
09340874 → ACNP
Volume
13
Issue
6
Year of publication
2000
Pages
385 - 401
Database
ISI
SICI code
0934-0874(200011)13:6<385:EAPOCT>2.0.ZU;2-X
Abstract
Chronic transplant dysfunction (CTD) is the predominant cause of late graft failure. The common histopathological feature in all transplanted organs i s intimal hyperplasia accompanied by organ specific lesions. The knowledge about CTD is incomplete, and there is no therapy to prevent or treat it. Th is review describes the current knowledge on the etiology of CTD, with emph asis on kidney transplants, and postulates a pathophysiologic route through which CTD may develop.