Interaction between factor VIII and LDL receptor-related protein - Modulation of coagulation?

Recent reports suggest that the multifunctional receptor low-density lipopr otein receptor-related protein (LRP) may contribute to the regulation of bl ood coagulation by mechanisms that differ from the simple removal of protea se/inhibitor complexes from the circulation. This possibility became appare nt from the observation that LRP is involved in down-regulation of Tissue F actor expression at the surface of monocytes and fibroblasts. Furthermore, coagulation Factor VIII and activated Factor IX (Factor IXa) have been iden tified as proteins that are able to bind to LRP. In the present review, the potential contribution of LRP to the regulation of the coagulation cascade through these novel pathways is discussed, with particular reference to th e interaction between LRP and coagulation Factor VIII. (Trends Cardiovasc M ed 2000;10:8-14). (C) 2000, Elsevier Science Inc.