Enteral nutrition (EN) and total parenteral nutrition (TPN) may provide lif
e-sustaining therapy for surgical patients. The duration of nutritional the
rapy (enteral or parenteral) implies distinct access routes. We review the
main aspects related to access routes for nutrient delivery. The enteral ro
ute, whenever feasible, is preferred. Far EN lasting less than 6 weeks, nas
oenteric tubes are the route of choice. Conversely, enterostomy tubes shoul
d be used for longer-term enteral feeding and can be placed surgically or w
ith fluoroscopic and endoscopic assistance. The first choice for patients w
ho will not be submitted to laparotomy is percutaneous endoscopic gastrosto
my. Postpyloric access, although not consensual, must be considered when th
ere is a high risk of aspiration. For intravenous delivery of nutrients las
ting less than 10 days, the peripheral route can be used. However, because
of frequent infusion phlebitis, its role is still in discussion. Central ve
nous catheters (CVCs) for TPN delivery may be (I) nonimplantable, percutane
ous, nontunneled-used for a few days to 3 to 4 weeks; (2) partially implant
able, percutaneous, tunneled-used for longer periods and permanent access;
or (3) totally implantable subcutaneous ports-also used for long-term or pe
rmanent access. The subclavian vein is usually the insertion site of choice
for central venous catheters. Implantable ports are associated with lower
rates of septic complications than percutaneous CVCs. The catheter with the
least number of necessary lumens should be applied. Central venous nutrien
t delivery can also be accomplished through peripherally inserted central c
atheters, which avoid insertion-related risks.