Acute effect of physiologic hyperinsulinaemia on serum leptin concentration in healthy young people

This study aimed to identify the acute effect of a physiologic dose of insu lin, enough to produce hyperinsulinaemia similar to that obtained in the po stprandial state, on serum leptin concentrations in healthy young people. A randomised, single blind controlled clinical trial was performed in 45 hea lthy, non-obese, young volunteers. Serum leptin concentration, uric acid, c reatinine levels and lipid profile were determined for all subjects. Insuli n suppression test modified with octreotide, used to produce physiologic hy perinsulinaemia, or saline infusion as control, were performed. Steady stat e insulin (SSI) concentrations were calculated and they represented the hyp erinsulinaemia state. Clinical characteristics and laboratory profiles were similar between groups. There was no significant difference between the ef fect of insulin or saline infusions on the serum leptin concentration. The acute effect of physiologic hyperinsulinaemia did not modify the serum lept in concentration in healthy young people.