Acyclovir-resistant varicella infection with atypical lesions in a non-HIVleukemic infant

Authors
Crassard, N Souillet, AL Morfin, F Thouvenot, D Claudy, A Bertrand, Y
Citation
N. Crassard et al., Acyclovir-resistant varicella infection with atypical lesions in a non-HIVleukemic infant, ACT PAEDIAT, 89(12), 2000, pp. 1497-1499
Citations number
16
Categorie Soggetti
Pediatrics,"Medical Research General Topics
Journal title
ACTA PAEDIATRICA
ISSN journal
08035253 → ACNP
Volume
89
Issue
12
Year of publication
2000
Pages
1497 - 1499
Database
ISI
SICI code
0803-5253(200012)89:12<1497:AVIWAL>2.0.ZU;2-M
Abstract
An HIV-negative infant presented with VZV primary infection during the main tenance therapy for megakaryoblastic leukaemia. The lesions were initially vesicular and necrotic but became verrucous and hyperkeratotic. A clinical resistance to acyclovir was suspected and confirmed by histologic and virol ogic studies. The patient was successfully treated by foscarnet. Conclusion : resistance of VZV to acyclovir may occur after a short treatment in a non -AIDS patient.