Aims. To identify risk factors for depression and anxiety that are more pre
valent in abstainers than in moderate drinkers and to estimate their contri
bution to U-shaped relationships of depression and anxiety with alcohol con
sumption. Design. Cross-sectional general population sample. Setting. Canbe
rra, Australia. Participants. 2725 subjects completed questionnaires, inclu
ding 1128 men and 1258 women aged 18-59 years. Measurements. Consumption ca
tegories from AUDIT quantity/frequency items: (1) non-drinkers (no alcohol
in the past year), (2) occasional drinkers (monthly or less), (3) lower-lev
el drinkers (up to 14 standard drinks per week for men and seven for women)
, (4) higher-level drinkers (up to 28 and 14 standard drinks per week, resp
ectively), and (5) those drinking at hazardous or harmful levels (over 28 a
nd 14 standard drinks per week, respectively). Goldberg and DSSI/sAD depres
sion and anxiety scales. A range of demographic, socio-economic, socio-envi
ronmental and personality factors. Findings. Non-drinkers were more likely
than lower-level drinkers to have low status occupations, poor education, c
urrent financial hardship, poor social support and recent stressful life ev
ents, and scored lower on extraversion, fun-seeking and drive. Many of thes
e characteristics also applied to hazardous/harmful drinkers. In multivaria
te models, these risk factors accounted for a substantial parr of the highe
r depression and anxiety scores of non-drinkers and occasional drinkers rel
ative to lower-level drinkers. Conclusions. Abstainers have a range of char
acteristics known to be associated with anxiety, depression and other facet
s of ill health, and these factors may contribute significantly to their el
evated levels of depression and anxiety.