Monitoring the crack epidemic through urine testing: establishment of routine detection methods

Abuse of crack continues to be of major concern. Because of limits to biolo gical testing, self-report has been the only mechanism for distinguishing c rack use from powder use. Researchers have reported that smoking crack gene rates unique pyrolysis products that are detectable in urine, but no study has addressed how these products could be used as the marker for crack use, neither has any study addressed how reliable is the detection technology. The National Institute of Justice has developed a project to address these issues. The project consisted of (1) inter views conducted with and urine s pecimens collected from 2327 adult arrestees; ( 2) development and validati on of procedures for routine GC/MS confirmation of crack use; and (3) estab lishment of standard profiles for two crack pyrolysis products, anhydroecgo nine methylester (AEME) and ecgonidine (ECD). We found that AEME and ECD co uld be detected in urine specimens for periods of up to 40 hours. Most impo rtantly, we demonstrated that to accurately measure crack use both AEME and ECD are necessary. Our results indicated that near ly 31% of the specimens were positive for undifferentiated cocaine, of which more than 88% were po sitive for crack. This resulted in crack prevalence rates of nearly 31% for females and 27% for males. These results will be used to fur ther monitor the crack epidemic and to provide information that can inform the developme nt of public policy as it relates to this drug.