Trovafloxacin-associated leukopenia

OBJECTIVE: To report a case of trovafloxacin-associated leukopenia, which o ccurred in a trauma:patient shortly after administration and resolved follo wing discontinuation of the drug. CASE SUMMARY: A 79-year-old white man was admitted to Yale New Haven Hospit al after sustaining partial amputation of his-right lower leg by an industr ial lawn mower. After successful resuscitation, he underwent complete right lower amputation and was treated with intravenous alatrofloxacin mesylate. He developed leukopenia that resolved after discontinuation of the drug. DISCUSSION: Trovafloxacin is a broad-spectrum synthetic fluoroquinolone use d for a wide variety of bacterial infection. We report, for the first time in the English-language literature, a case of trovafloxacin-associated leuk openia: The leukopenia resolved promptly after discontinuation of the drug. This association is further supported by the exclusion of other potential causes for this adverse. effect. CONCLUSIONS: Leukopenia is a well-recognized adverse effect of several drug s. We report of trovalfloxacin-associated leukopenia during treatment of a trauma patient. Healthcare personnel should be aware of this possible adver se reaction in patients treated with trovafloxacin.