ESR dosimetry of Sr-89 and Sm-153 in bone

The radiation absorbed dose in the rabbit bone delivered by Sm-153-EDTMP (s amarium ethylenediamine tetra methylene diphosphonic acid) and (SrCl2)-Sr-8 9 (strontium chloride) was measured by means of electron spin resonance (ES R). These radioisotopes are used in systemic radiotherapy for palliation of painful bone metastases. The knowledge of the dose is important in order t o avoid side effects to the bone marrow. The ESR radiation dose signal was calibrated by the additive dose method using cobalt-60 gamma rays. For Sm-1 53-EDTMP, the bone doses in three rabbits were (4 +/- 2), (5 +/- 1) and (5 +/- 2) cGy kg/MBq. For (SrCl2)-Sr-89, a dose of (2 +/- 1) cGy kg/MBq was fo und in one rabbit. (C) 2001 Elsevier Science Ltd, All rights reserved.