Does [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]-dichloroplatinum(II) act on the hormone-sensitive, murine breast cancer as a biological response modifier? Part II. Studies on the influence of [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) on the specific immune defense in MXT-M-3,2 breast cancer bearing mice

The anti-tumor activity of [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethyl enediamine] dichloroplatinum(II) on the MXT-M-3,2 breast cancer implanted i nto B6D2F(1) mice was not significantly reduced by splenectomy or co-admini stration of cyclosporine A. Neither did the use of T-lymphocyte-deficient N MRI (nu/nu) mice as hosts substantially influence its anti-tumor effect. Ob viously, [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl) ethylenediamine]dichlo roplatinum(II) does not act by an enhancement of the specific immune defens e.